Difference Between Exotoxin and Endotoxin

Serial; no.
Property
Exotoxin
Endotoxin
1.
Bacterial source
Mostly from gram positive bacteria
Gram negative bacteria
2.
Relation to microorganism
Metabolic product of growing cell
Present in LPS of outer membrane of cell wall and released with destruction of cell or during cell division
3.
Protein content
Proteins usually with two parts (A-B)
Liquid portion of LPS of outer membrane
4.
Heat stability
Unstable can usually be destroyed at 60-80 degree centigrade
Stable can withstand autoclaving 121 degree centigrade for 1 hour
5.
Pharmacology
Each has a  highly characteristic mechanism of action
General such as fever, weakness aches and shock all produce the same effects
6.
Toxicity
High
 Low
7.
Fewer producing
No
 Yes
8
Representative disease
Gas gangrene,  Tetanus botulism, Diphtheria, Scarlet fever
Typhoid fever
9
Lethal dose
Small
Considerable larger
10.
Example
Streptococcus pyogens
 Salmonella typhus

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