Serial; no.
|
Property
|
Exotoxin
|
Endotoxin
|
1.
|
Bacterial source
|
Mostly from gram positive bacteria
|
Gram negative bacteria
|
2.
|
Relation to microorganism
|
Metabolic product of growing cell
|
Present in LPS of outer membrane of cell wall and released with destruction of cell or during cell division
|
3.
|
Protein content
|
Proteins usually with two parts (A-B)
|
Liquid portion of LPS of outer membrane
|
4.
|
Heat stability
|
Unstable can usually be destroyed at 60-80 degree centigrade
|
Stable can withstand autoclaving 121 degree centigrade for 1 hour
|
5.
|
Pharmacology
|
Each has a highly characteristic mechanism of action
|
General such as fever, weakness aches and shock all produce the same effects
|
6.
|
Toxicity
|
High
|
Low
|
7.
|
Fewer producing
|
No
|
Yes
|
8
|
Representative disease
|
Gas gangrene, Tetanus botulism, Diphtheria, Scarlet fever
|
Typhoid fever
|
9
|
Lethal dose
|
Small
|
Considerable larger
|
10.
|
Example
|
Streptococcus pyogens
|
Salmonella typhus
|
Difference Between Exotoxin and Endotoxin
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment