Difference between live and killed vaccines:
1.
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Factors
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Live vaccine
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Killed vaccine
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2.
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Definition
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A vaccine prepared from living attenuated organisms or from viruses that have been attenuated but can still replicate the cells of the host organism.
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Killed vaccines are suspension of bacteria or of viruses by disinfectants such as phenol or formaldehyde.
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2.
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Manufacturing
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Easy to manufacture
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More complicated and expensive to manufacture.
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3.
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Safety
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Can be dangerous to applicator if person injects himself, e.g. anthrax and contagious abortion (brucellous) vaccines.
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Safe
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4.
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Storage
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Handling is critical
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Less critical
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5.
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Virulence
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There are always possibilities that the antigen can return to virulence and cause disease.
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The antigen is inactivated, thus cannot return to virulence (can cause illness).
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6.
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Immunity
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Immunity develops quickly and can have a longer duration (sometimes life long).
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Immunity takes longer time to develop.
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7.
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Response level
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Strong immune response.
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Weak immune response.
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8.
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Stability
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Highly unstable
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Quite stable
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9.
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Booster dose requirement
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Needs no booster dose.
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Needs booster dose.
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10.
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Stimulation of cells
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CD4+ and CD8+ stimulation
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Mainly CD4+ stimulation.
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11.
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About adjuvant
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Adjuvants are not critical.
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Adjuvants are critical.
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12.
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Example
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Live vaccines are available for diseases such as Mumps, Rubella, Measles, Yellow fever, Varicella and influenza( administered intransally, BCG, Small pox etc.
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Killed vaccines are available
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